New Flame Assist 2017 Activation

One of these downstream homeostatic functions is glucose homeostasis and, in particular, hepatic glucose production (Lin et al., 2010). Both BDE-47 and OPFR elevated fasting glucose levels in males, indicating an increase in hepatic glucose production either directly by altering liver glucose metabolism or indirectly by altering the neuroendocrine control of glucose production. FR did not have an effect in females, most likely due to the disruptive effects of ovariectomy (loss of E2) on glucose metabolism. Indeed, glucose clearance was augmented by EE2 and BDE-47 in females, recapitulating the effects of E2 replacement in OVX female rodents (Yasrebi et al., 2017). The activation of ERα increases glucose tolerance by regulating the glucose transporter type 4 (GLUT4) expression and activity in skeletal muscle (Gorres et al., 2011). Thus, ERα KO females exhibit impairments to glucose clearance (Yasrebi et al., 2017) and were not examined in this study.

New Flame Assist 2017 Activation

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